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The absolute bioavailability of tramadol was 73% in males and 79% in females The plasma clearance was 64 mL/min/kg in males and 57 mL/min/kg in females following a 100 mg IV dose of tramadol Following a single oral dose, and after adjusting for body weight, females had a 12% higher peak tramadol concentration and a 35% higher area under the concentrationtime curveThe analgesic tramadol has minimal effect on gastrointestinal motor function Clive H Wilder4mith & Andrea Bettiga colour and were dispensed from a coded bottle using a calibrated pipette Volunteers took the study drug at home, but telephoned the study monitor at each time of dosing to corifirni compliance and report sideeffects Volunteers attended the research ward for10 · The major Tramadol side effects could be abdominal or stomach fullness, abnormal or decreased touch sensation, blisters under the skin, bloating, blood in the urine, blood pressure increased, blurred vision, change in walking and balance, chest pain or discomfort, chills, convulsions (seizures), darkened urine, difficult urination, dizziness or lightheadedness when
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